Hotel holiday rentals in Upstate South Carolina

Find and book unique hotel rentals on Airbnb

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Popular amenities for hotel rentals in Upstate South Carolina

Family-friendly hotel rentals

Superhost
Hotel room in Clemson
5 out of 5 average rating, 7 reviews

Two private rooms with bathroom

LindsayRating, 5 stars19 months ago
Everything about our stay at Diana’s was perfect! Location, cleanliness, attentiveness and all the extras! She made us feel like family and truly cared about us having a nice and relaxing time while visiting! We will be returning guests, cannot say enough great things about this wonderful lady and her place! Go TIGERS!
Superhost
Hotel room in Dillsboro
4.85 out of 5 average rating, 73 reviews

Dillsboro Inn Family Suite

CaroleRating, 5 stars4 weeks ago
Fantastic place on the river! Thomas is a great host and on my "great place to visit again" list.
Hotel room in Ashville
4.6 out of 5 average rating, 93 reviews

Brookstone Lodge Asheville Biltmore Village Area

MichelleRating, 5 stars13 months ago
I didn’t talk to Paul while I was there. This is a hotel that is right by the interstate but I didn’t hear the noise in my room. It was nice and clean. Continental breakfast is included. 5 minute drive to Biltmore. Great value!
Hotel room in Ashville
4.74 out of 5 average rating, 82 reviews

Brookstone Lodge an Choice Ascend Collection Hotel

DevenRating, 5 stars1 month ago
Great place to stay. Stay is extremely accommodating
Hotel room in Ashville
4.58 out of 5 average rating, 33 reviews

Brookstone Lodge Hotel Easy Access I-40 Downtown

JessicaRating, 5 stars9 months ago
Our stay at Brookstone Lodge was great - our room was very clean and spacious and had all the listed amenities. The place was also just a few minutes drive to Biltmore, and many restaurants and amenities. We also appreciated Leslie’s great customer service - he went above and beyond to help us deal with an unexpected wedding attire emergency we had. We highly recommend Brookstone Lodge!
Private room in Lake Junaluska
4.69 out of 5 average rating, 264 reviews

The Providence Lodge and Gallery

MiriamRating, 5 stars1 month ago
Jason is an excellent host. A lodger had caused an issue, and Jason was on it right away and solved the issue in minutes! I have stayed at this airbnb several times, and it has always met my expectations. Book it!
Hotel room in Tryon
4.91 out of 5 average rating, 55 reviews

GreenLife Inn at Mimosa Room 202

SueRating, 5 stars48 months ago
Oh my gosh! My friend and I had a girls' weekend in the Tryon area visiting the local wineries and we stayed at the Green Life Inn, and it was a great experience! Mary's special touches were amazing! There were snacks & water in the room, top-quality soaps and shampoo were provided, and the bed linens were AMAZING! To top it all off, Mary provided quite the spread of food for breakfast. Homemade (yummy) muffins, cheesy hashbrowns with sausage, hard-boiled eggs, yogurt, fruit, juice, coffee and much more! We will definitely stay there again! Thank you Mary for your hospitality!
Hotel room in Ashville
4.65 out of 5 average rating, 82 reviews

Brookstone Lodge Boutique Hotel Near City Center

DeannaRating, 5 stars7 months ago
We stayed here for our trip to the Biltmore! Perfect location, nine minutes from the estate, twelve minutes from downtown which has amazing food! Would highly recommend Tupelo Honey and Flour for a breakfast sandwich! The location is a hotel! Everything is completely clean and the beds were beyond comfortable. We absolutely want to come back to Asheville and I absolutely would come back to stay! :)

Hotel rentals with a pool

Superhost
Hotel room in Cashiers

Lodges at Trillium- 2 bedrooms

KeithRating, 5 stars1 month ago
Great place! Tremendous value for the money. Scott's communication was awesome and helpful. I would highly recommend this place. Quiet, beautiful and serene.
Resort in Hendersonville
4.59 out of 5 average rating, 59 reviews

Room 304 Honeymoon Suite King Bed & Queen Sofa

KristinaRating, 5 stars15 months ago
Dropped in for the night. Check in was a breeze! We can’t wait to stay again!
Hotel room in Columbia
4.5 out of 5 average rating, 10 reviews

Minutes From Lake Murray Views | Free Parking

SarahRating, 5 stars3 weeks ago
My room was amazing! No issue at all. I didn't like that the hallway smelled like weed, and people were outside smoking weed.
Superhost
Resort in Gatlinburg
4.86 out of 5 average rating, 37 reviews

Treetops Resort Gatlinburg 2BD/2BA Condos SUNDAY

PennyRating, 5 stars8 months ago
Location was great, close to everything yet peaceful. Great amenities. Place was clean and had what we needed for our stay.
Hotel room in Gatlinburg
4.75 out of 5 average rating, 4 reviews

Westgate Smoky Mountain Resort

TuesdayRating, 5 stars20 months ago
Meredith is a great host! She is very responsive and helpful. My fiancé and I had a great time! The views are absolutely amazing!
Guest favourite
Private room in Irmo
4.88 out of 5 average rating, 17 reviews

Relax in beach themed room.

MarcelleRating, 5 stars7 months ago
Ashlee place was peaceful and clean , great conversation from the get Go we hit it off very friendly, u ever wanna feel like your home get to Ashlee place u will not be disappointed, we will differently be back thank u for having us till the next time see u soon Marcelle
Hotel room in Gatlinburg
5 out of 5 average rating, 3 reviews

Mountain Loft Resort

DavidRating, 5 stars26 months ago
I have been to Mountain Loft before and normally have a better view of the Mountains. This time around the side of a dirt hill and parking lot. Be aware of the staff working the vehicle pass issuance, they will invite you to one of their Blue Green (Time Share) meetings. It’s and easy no if you have ever been to one, don’t let them sucker you in with their I’ll pay you $150 if you do attend. I’m sure walking through hot coals is a better experience. Anyways, room was good enough for a quick weekend stay for a soccer tournament.
Hotel room in Gatlinburg
4.62 out of 5 average rating, 29 reviews

Honeymoon Cottage #8

JosephRating, 5 stars3 months ago
Me and my wife really enjoyed our stay here. Very good location and view, whirlpool tub was great.

Hotel rentals with a patio

Hotel room in Hendersonville
4.9 out of 5 average rating, 10 reviews

Renovated Double Queen Stay

MelissaRating, 5 stars2 months ago
This was the perfect cozy place for a party of 2, perfect location, room was perfect, comfortable beds!!
Private room in Franklin
5 out of 5 average rating, 6 reviews

Cat Creek Lodge - Cowee Mountain

MichealRating, 5 stars5 months ago
It was a wonderful place to stay. Great responsiveness from the host.
Hotel room in Waynesville
New place to stay

Camp Vibes & Fire Pit @ '40s Inn

JasmynnRating, 5 stars5 days ago
The place was wonderful, even more beautiful in person. It was so quiet and peaceful.
Top guest favourite
Resort in Gatlinburg
5 out of 5 average rating, 6 reviews

Beautiful Mountain Resort - Gatlinburg

CoryRating, 5 stars5 months ago
Amy was very kind, helpful and responsive throughout the entire booking process. Where we stayed was very comfortable and had amazing views. The location was perfect too right between pigeon forge and gatlinburg. Would highly recommend.
Hotel room in Bryson City

Lost Cove @ Long View Resort

RobertRating, 5 stars4 months ago
This place was beautiful and quiet! The sunrise and sunset were breathtaking
Private room in Inman

The Cedar Room at Riverbend

PaigeRating, 5 stars1 month ago
Nice rooms and great host!
Hotel room in Ashville
5 out of 5 average rating, 7 reviews

Biltmore Hideaway Villa

CathyRating, 5 stars14 months ago
Absolutely perfect!! The location is amazing….walkable to shopping and dining. Getting to and from the condo was super easy too . Can’t wait to stay again 😊
Hotel room in Highlands

Outpost Inn Highlands

AmyRating, 5 stars4 weeks ago
Words cannot describe how how beautiful this place is , it is a must see , so unique so beautiful

Destinations to explore