Guest house holiday rentals in Pickens County

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Top-rated guest house rentals in Pickens County

Guests agree: these guest house rentals are highly rated for location, cleanliness and more.

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Top guest favourite
A well-lit living area features a comfortable sofa and a decorative armchair, arranged around a wooden coffee table. The walls display framed photographs, and large windows allow natural light to brighten the space. A ceiling fan adds to the room's inviting atmosphere.
Guest house in Clemson
5 out of 5 average rating, 24 reviews

Riggs Drive Gameday Getaway

Experience the heart of Clemson like never before in our newly built over-garage apartment, situated less than 1 mile from Death Valley. Leave your car parked and immerse yourself in the electric gameday atmosphere. Less than a 1/2 mile from downtown, our private apartment is the perfect home base for your gameday festivities. This apartment boasts a fully equipped kitchen, ideal for tailgate preparations. Nestled in the heart of Clemson, stroll down memory lane, reliving your college days.

Top guest favourite
A porch swing is set on a wooden deck, adorned with plush cushions featuring intricate patterns. Lush greenery and colorful flowers are visible in the background, adding vibrancy to the serene outdoor setting.
Guest house in Six Mile
4.96 out of 5 average rating, 168 reviews

Your Charming Country Cottage

Whether you need a country getaway or a place to lay your head after a football game, our cottage in the foothills of upstate SC is the perfect spot for both. You’ll find us tucked away just outside the quaint little town of Six Mile, 10 miles north of Clemson University and in close proximity to 3 of the upstate's favorite lakes: Lake Keowee, Lake Jocassee and Lake Hartwell. Here you’ll enjoy the serenity of country life without feeling “too far out" or away from all the upstate has to offer.

Guest favourite
A charming cabin is nestled among towering trees, with a sloped metal roof and rustic log walls. Lush greenery surrounds the property, while vibrant blue hydrangeas bloom in the foreground. A fire pit with seating is positioned to the right, creating an inviting outdoor space.
Guest house in Sunset
4.92 out of 5 average rating, 412 reviews

Mountain Cabin on Creek at Jocassee Gorge.

Welcome to Laurel Valley. A tiny, sleepy neighborhood at the top of a mountain, hidden from the hustle of civilization. This adorable cabin is nestled in beautiful Jocassee Gorge. Minutes away from multiple attractions including Sassafras Mountain and Twin Falls. Property borders thousands of acres of protected land with 5 star trails . This mountain cabin is in a unique setting that time forgot. The rushing creek outside helps you to peel off the world and get a great night's sleep.

Top guest favourite
A rustic cabin is nestled among the trees, with a gravel pathway leading to the entrance. The exterior features wooden siding and a metal roof, complemented by landscaped stones and potted plants. Seasonal decor is present, enhancing the welcoming atmosphere.
Guest house in Pickens
5 out of 5 average rating, 19 reviews

Fairy Forest Cabin with Hot Tub at Table Rock

Adventure and relaxation await you! Set half a mile off the road, surrounded by forest, you’ll feel like you’re far away from the demands of life as you soak in the hot tub. But you are right in the golden corner of SC, NC, GA mountains with the best of hiking, kayaking, cycling and dining nearby! Only 28 miles from Greenville, Clemson and Brevard NC with Table Rock State Park and Lakes Jocassee and Keowee a few minutes away. The perfect couple’s getaway! Use of SC State Park pass included.

Top guest favourite
A hand is shown holding a ceramic cup with the phrase 'Rise and shine' printed on it. The background features a serene lake reflecting a colorful sunset, with warm hues spreading across the sky and the water. A dock can be seen in the distance.
Guest house in Six Mile
5 out of 5 average rating, 24 reviews

Lakeside Haven on Lake Keowee

Relax at this cozy lakefront studio on Lake Keowee with access to kayaks, paddleboards, a dock, fire pit, and pool. Perfect for unwinding or exploring, it's close to state parks with hiking trails and just a short drive to Clemson University-great for football weekends. The studio includes a full kitchen, private bath and in-unit washer/dryer providing all the comforts of home. Whether you're here for adventure or relaxation, this lakeside retreat has everything you need.

Guest favourite
A spacious living area is presented with high ceilings. A neutral-toned sofa and an armchair are complemented by a coffee table at the center. Colorful artwork, including a world map, adorns the walls, contributing to a vibrant yet relaxing atmosphere.
Guest house in Pendleton
4.9 out of 5 average rating, 270 reviews

La Bella Farm

Do you want to be close to Clemson(11 miles), Anderson(9 miles) OR Greenville(20miles)! Do you want to just get away from all of the noise and busy life. Then you have found your spot! This is a great detached garage apartment. Settled in the quiet country side of Pendleton SC. 1 bedroom&1 bathroom with an additional sofa bed&blow up mattress. Great view of nothing but beautiful land from the kitchen window yet minutes away from Death Valley,restaurants,shopping and 85.

Guest favourite
The exterior of Little Blue is shown, featuring a one-story house with a front porch and steps leading up to it. Surrounding trees display vibrant autumn foliage, while a natural landscape covers the ground, hinting at a serene, countryside atmosphere.
Guest house in Sunset
4.82 out of 5 average rating, 91 reviews

Little Blue Cottage on the Jocassee Wilderness

Little Blue, named because it's surrounded by wild blueberries, is situated just steps from the Jocassee Wilderness Area listed by National Geographic as 9th out of “50 of the World's Last Great Places.” It's located on the property of Heart Ridge Retreat Center. Guests will have access to all the retreat center grounds which includes a well-stocked lake (bring your rod). It's also centrally located to many trails, waterfalls, state parks, and lakes.

Top guest favourite
A modern studio space is presented with a comfortable sectional sofa facing a wall-mounted television. A cozy bed is positioned in the background. A decorative plant adds a touch of greenery, and ambient lighting enhances the relaxed atmosphere.
Guest house in Easley
5 out of 5 average rating, 37 reviews

The Hideaway Station

Here you will find a cute and surprisingly modern studio apartment tucked all the way in the back of a Victorian countryside style property, completely private to any person who stays. Walk to Downtown Easley, where living has never been better as new restaurants are flocking to the area. The Doodle Trail, a repurposed rail line, offers an 8 mile pathway connecting Easley & Pickens, and features new playgrounds on each end.

Guest favourite
A spacious studio cottage interior features a cozy seating area with a green upholstered chair and hardwood flooring. Natural light streams through multiple windows, illuminating a queen bed with decorative accents. A dining table and kitchenette area are visible, enhancing the functional living space.
Guest house in Pelzer
4.95 out of 5 average rating, 82 reviews

Quaint guest cottage in Upstate

This special property is near Greenville, Anderson, Clemson and more. Located just 3.6 miles from I-85 on Main Street West Pelzer, you can go any direction making this the perfect home base for exploring the Upstate. This charming cottage combines comfort, city and country. We strive to "think of everything" so your stay is fabulous. And you will love coming "home" to The Canning House after all your daily adventures!

Top guest favourite
The exterior of the property is shown, featuring yellow siding complemented by dark shutters on the windows. A single door with glass panels is visible, providing a welcoming entrance. A grassy area is located at the base of the wall, enhancing the outdoor setting.
Guest house in Liberty
4.93 out of 5 average rating, 202 reviews

Holly Hideaway! 10 Highway miles to Clemson U!

Holly Hideaway is nestled between Greenville and Clemson, in the small town of Liberty. It's perfect for business travelers, couples, Clemson parents, alumni, and small families. Tiled throughout for cleanliness. Privacy, tranquility, and clean, comfortable accommodations are what we provide. We are 10 minutes from Clemson and 3 miles from SWU. The Hideaway now offers Wi-Fi and Smart TV.

Guest favourite
The studio features a spacious sleeping area with a large bed and a comfortable futon couch. A coffee table sits in front of the couch, and an electric fireplace is positioned nearby. A wall-mounted TV displays a serene image, while stylish lighting fixtures enhance the decor.
Guest house in Greenville
4.93 out of 5 average rating, 193 reviews

Gilded Frog Guesthouse. Rainfall Shower, King Bed

Welcome to the Gilded Frog Studio. Conveniently located between Greenville and Easley and only minutes from I85, we are positioned right in the heart of the growing Powdersville area. Whether you're visiting Greenville or looking for a local place to stay to catch a Clemson game, we offer the amenities you need to make your stay effortlessly enjoyable.

Top guest favourite
Large glass doors open to a serene outdoor space with natural stone pathways and grassy areas. Trees are visible in the background, and a seating area with wooden furniture is arranged on a patio. Soft natural light fills the room.
Guest house in Pendleton
5 out of 5 average rating, 34 reviews

Nested Studio Woodscape

Escape to our modern rustic and refined small studio apartment, nestled in the country. Tucked away in the trees, it sleeps four, with one bathroom. Experience the perfect blend of serene seclusion and contemporary comfort in this charming retreat. Ideal for nature lovers and close to nearby attractions. Book now for an unforgettable getaway!

Popular amenities for guest house rentals in Pickens County