
Guest house holiday rentals in Pickens County
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Top-rated guest house rentals in Pickens County
Guests agree: these guest house rentals are highly rated for location, cleanliness and more.

Riggs Drive Gameday Getaway
Experience the heart of Clemson like never before in our newly built over-garage apartment, situated less than 1 mile from Death Valley. Leave your car parked and immerse yourself in the electric gameday atmosphere. Less than a 1/2 mile from downtown, our private apartment is the perfect home base for your gameday festivities. This apartment boasts a fully equipped kitchen, ideal for tailgate preparations. Nestled in the heart of Clemson, stroll down memory lane, reliving your college days.

Your Charming Country Cottage
Whether you need a country getaway or a place to lay your head after a football game, our cottage in the foothills of upstate SC is the perfect spot for both. You’ll find us tucked away just outside the quaint little town of Six Mile, 10 miles north of Clemson University and in close proximity to 3 of the upstate's favorite lakes: Lake Keowee, Lake Jocassee and Lake Hartwell. Here you’ll enjoy the serenity of country life without feeling “too far out" or away from all the upstate has to offer.

Mountain Cabin on Creek at Jocassee Gorge.
Welcome to Laurel Valley. A tiny, sleepy neighborhood at the top of a mountain, hidden from the hustle of civilization. This adorable cabin is nestled in beautiful Jocassee Gorge. Minutes away from multiple attractions including Sassafras Mountain and Twin Falls. Property borders thousands of acres of protected land with 5 star trails . This mountain cabin is in a unique setting that time forgot. The rushing creek outside helps you to peel off the world and get a great night's sleep.

Fairy Forest Cabin with Hot Tub at Table Rock
Adventure and relaxation await you! Set half a mile off the road, surrounded by forest, you’ll feel like you’re far away from the demands of life as you soak in the hot tub. But you are right in the golden corner of SC, NC, GA mountains with the best of hiking, kayaking, cycling and dining nearby! Only 28 miles from Greenville, Clemson and Brevard NC with Table Rock State Park and Lakes Jocassee and Keowee a few minutes away. The perfect couple’s getaway! Use of SC State Park pass included.

Lakeside Haven on Lake Keowee
Relax at this cozy lakefront studio on Lake Keowee with access to kayaks, paddleboards, a dock, fire pit, and pool. Perfect for unwinding or exploring, it's close to state parks with hiking trails and just a short drive to Clemson University-great for football weekends. The studio includes a full kitchen, private bath and in-unit washer/dryer providing all the comforts of home. Whether you're here for adventure or relaxation, this lakeside retreat has everything you need.

La Bella Farm
Do you want to be close to Clemson(11 miles), Anderson(9 miles) OR Greenville(20miles)! Do you want to just get away from all of the noise and busy life. Then you have found your spot! This is a great detached garage apartment. Settled in the quiet country side of Pendleton SC. 1 bedroom&1 bathroom with an additional sofa bed&blow up mattress. Great view of nothing but beautiful land from the kitchen window yet minutes away from Death Valley,restaurants,shopping and 85.

Little Blue Cottage on the Jocassee Wilderness
Little Blue, named because it's surrounded by wild blueberries, is situated just steps from the Jocassee Wilderness Area listed by National Geographic as 9th out of “50 of the World's Last Great Places.” It's located on the property of Heart Ridge Retreat Center. Guests will have access to all the retreat center grounds which includes a well-stocked lake (bring your rod). It's also centrally located to many trails, waterfalls, state parks, and lakes.

The Hideaway Station
Here you will find a cute and surprisingly modern studio apartment tucked all the way in the back of a Victorian countryside style property, completely private to any person who stays. Walk to Downtown Easley, where living has never been better as new restaurants are flocking to the area. The Doodle Trail, a repurposed rail line, offers an 8 mile pathway connecting Easley & Pickens, and features new playgrounds on each end.

Quaint guest cottage in Upstate
This special property is near Greenville, Anderson, Clemson and more. Located just 3.6 miles from I-85 on Main Street West Pelzer, you can go any direction making this the perfect home base for exploring the Upstate. This charming cottage combines comfort, city and country. We strive to "think of everything" so your stay is fabulous. And you will love coming "home" to The Canning House after all your daily adventures!

Holly Hideaway! 10 Highway miles to Clemson U!
Holly Hideaway is nestled between Greenville and Clemson, in the small town of Liberty. It's perfect for business travelers, couples, Clemson parents, alumni, and small families. Tiled throughout for cleanliness. Privacy, tranquility, and clean, comfortable accommodations are what we provide. We are 10 minutes from Clemson and 3 miles from SWU. The Hideaway now offers Wi-Fi and Smart TV.

Gilded Frog Guesthouse. Rainfall Shower, King Bed
Welcome to the Gilded Frog Studio. Conveniently located between Greenville and Easley and only minutes from I85, we are positioned right in the heart of the growing Powdersville area. Whether you're visiting Greenville or looking for a local place to stay to catch a Clemson game, we offer the amenities you need to make your stay effortlessly enjoyable.

Nested Studio Woodscape
Escape to our modern rustic and refined small studio apartment, nestled in the country. Tucked away in the trees, it sleeps four, with one bathroom. Experience the perfect blend of serene seclusion and contemporary comfort in this charming retreat. Ideal for nature lovers and close to nearby attractions. Book now for an unforgettable getaway!
Popular amenities for guest house rentals in Pickens County
Family-friendly guest house rentals

Mountain Cabin on Creek at Jocassee Gorge.

Holly Hideaway! 10 Highway miles to Clemson U!

Fairy Forest Cabin with Hot Tub at Table Rock

Camper at Hickory Lodge and Guesthouse

Lakeside Haven on Lake Keowee

La Bella Farm

Gilded Frog Guesthouse. Rainfall Shower, King Bed

Rest Your Caboose Cottage
Guest house rentals with a patio

Cottage On Hemlock Hill

Pickens Paradise

Downtown Clemson Guest Suite!

Vacation Home Clemson and Lakes

Poolside Paradise Guesthouse
Guest house rentals with a washing machine and dryer

Gameday guest home near Death Valley

Downtown Clemson Guest Suite!

Adorable Cottage 2 mi. from Death Valley

Camper at Hickory Lodge and Guesthouse

Clemson Carriage House - NEW!

Vacation Home Clemson and Lakes

Quaint guest cottage in Upstate

Lakeside Haven on Lake Keowee
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- Guest house rentals South Carolina
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- Blue Ridge Parkway
- Black Rock Mountain State Park
- River Arts District
- Gorges State Park
- The North Carolina Arboretum
- Tallulah Gorge State Park
- Tugaloo State Park
- Table Rock State Park
- Chimney Rock State Park
- Mountaintop Golf & Lake Club
- Ski Sapphire Valley
- Lake Lure Beach and Water Park
- Maggie Valley Club
- Tryon International Equestrian Center
- Jump Off Rock
- Wade Hampton Golf Club
- Biltmore Forest County Club
- Vineyards for Biltmore Winery
- Old Edwards Club
- French Broad River Park
- Victoria Valley Vineyards
- Woolworth Walk
- Thomas Wolfe Memorial
- Discovery Island