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Guest house holiday rentals in Los Santos Province

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Top-rated guest house rentals in Los Santos Province

Guests agree: these guest house rentals are highly rated for location, cleanliness and more.

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Top guest favourite
Palm trees stand gracefully on a lush green hillside, leading to a welcoming casita with a tiled roof. The vibrant landscape showcases tropical foliage under a clear sky, indicating a serene and natural environment.
Guest house in Pedasi
5 out of 5 average rating, 31 reviews

A Remote Paradise in nature - Ocean View

'Tres-Palmas' sea and nature at its best! A remote hideaway on the Pacific Coast of Panama, but yet close enough to nearby towns and entertainment, Tres Palmas is the perfect place for an invigorating holiday. It is more than just a place to stay, we offer our guests personalized attention through fully equipped facilities and services for your comfort and well being. We enjoy getting to know our guests, sharing life stories and greeting you with an authentic smile for an unforgettable stay.

The exterior of a cozy one-bedroom cabana is shown, featuring a traditional tiled roof and a blend of brick and stucco walls. A green chair is positioned on the porch, which overlooks a grassy area. A thatched rancho is visible in the background, surrounded by lush greenery.
Guest house in Cañas

Cozy & quiet cabin in Cañas

It is a cozy one-bedroom unit, with a closet, a bathroom with separated toilet area, a porch and a rancho. Nestled amidst the serene hills of Canas, the property offers a tranquil retreat with a picturesque ocean view. Wake up to the enchanting melodies of howler monkeys and local birds, immersing yourself in the beauty of nature every morning. While the cabana doesn’t have its own kitchenette, fret not! You’ll have access to a nearby fully equipped community kitchen, shared between 2-3 people.

Top guest favourite
The spacious dining area features a wooden table surrounded by chairs, with vibrant flowers as a centerpiece. Large glass doors open to a green outdoor space, allowing natural light to fill the room and offering a view of the surrounding trees and patio.
Guest house in Playa Los Destiladeros
5 out of 5 average rating, 10 reviews

Ginger Apartment/House for a violinist

Relájate en esta escapada única y tranquila en un barrio privado. A solo 5 minutos a pie hasta la playa, desde la casa puedes escuchar el agua de la quebrada y el canto de los pájaros en los árboles, disfrutar de la naturaleza y la paz que brinda el entorno. El alojamiento dispone de una gran terraza con área de barbacoa, baño y ducha externa y, descendiendo, un deck al borde de la quebrada. Ideal para los amantes de la naturaleza, trabajo remoto, surf, yoga, meditación, caminatas y pesca.

Guest house in Cambutal

Tiger Beach Cottage @ Los Buzos

A relaxing getaway right across the beach for anyone looking for time in paradise. Located at Los Buzos Resort and its world famous fishing & adventure lodge where guests have direct access to the many activities and amenities it has to offer like its 400 acre private nature reserve Parque Los Buzos where guests can experience the lush Panamanian wilderness and wildlife on more than 40k of trails. Los Buzos has many thrilling activities waiting. We live where the adventure is.

A bright and airy bedroom features a spacious bed with crisp white linens and large glass doors that open to reveal views of the ocean and surrounding greenery. Natural light fills the room, highlighting decorative plants and a cozy seating area.
Guest house in Playa Venao

A beautiful beachfront guest house

A perfect jungle-ocean sanctuary in Playa Venao, right across from the main surf point. Open views of the ocean and jungle, tropical vibes, one minute from the surf break and a short walk to town—secluded enough for peace, but close enough to enjoy the action, especially during Venao’s legendary festival weekends. Venao’s green season (roughly May–December-ish) is stunning—nature at its peak. And from around July to October-ish, you can literally watch whales from bed, daily.

Top guest favourite
A refreshing swimming pool sits in the foreground, complementing the rustic building behind it. Lush greenery and potted plants surround the area, enhancing the natural setting. A shaded patio area with outdoor seating is visible, offering a serene environment for relaxation.
Guest house in La Enea
4.96 out of 5 average rating, 48 reviews

Country House with Pool in La Enea de Guararé

Far from the capital city, come to enjoy Panamanian folklore in a rustic but cozy space living a native experience. Lounge in the pool or lounge in a hammock, breathe fresh air, close to the ocean, surrounded by wide, natural gardens for a good walk. Close to the Puerto de Guararé where you will enjoy the best seafood and drinks or enjoy the heart of the best folklore event highlighting the traditions and the best Panamanian chickens.

A cozy sleeping area features a plaid bedspread on a spacious bed. Adjacent to the bed, a small wooden shelf provides a convenient surface. A fan is mounted on the wall, and natural light filters in through a nearby window adorned with bamboo blinds.
Guest house in Las Tablas

Accommodation in Las Tablas

Enjoy the simplicity of this quiet and central accommodation. Just a 10-minute walk from Las Tablas village center, birthplace of Panamanian culture and folklore with its activities and festivities. It offers the basic services for short stays. The owner can provide information to the guest to visit nearby beaches and indicate means of transportation to visit nearby districts such as Pedasí and activities of interest in the province.

Guest favourite
A charming structure is framed by lush greenery, showcasing a rustic exterior with a terracotta roof and red accents. A small porch features a table and two chairs, inviting relaxation in this serene environment.
Guest house in Guararé
4.88 out of 5 average rating, 17 reviews

La Casita del Abuelo

This private place with full private bathroom is perfect for solo adventurers or a couple, seeking peace and relaxation in an authentic environment near the beach and town. This cute hideaway is located minutes’ walks from town and bus stop and about two miles from the nearest beach. It is a new, very clean, private, secure place, and it includes private use of an adjacent bohio with hammocks, barbecue grill, and bar.

A colorful hammock is draped between two wooden posts on a porch, surrounded by lush greenery. A person is seen resting peacefully, reclined with their back against the hammock. The setting invites relaxation and embodies a connection to nature.
Guest house in Cambutal
4.86 out of 5 average rating, 7 reviews

"La Jungla" Cabaña close to the beach

New room with shared kitchen and private bathroom close to the beach. You can enjoy all that Cambutal has to offer from this place. It has easy access so you dont need 4x4. Its located 500m from the beach, or 5 mins walking. The room has its own little green area and a large bathroom in the back. We try yo be close to nature and have a cool community here. We are happy to welcome new comers and old faces to Cambutal :)

Guest house in Cambutal
5 out of 5 average rating, 3 reviews

Casita Verde 411

Ocean View Jungle Casita • 500 m from 411 Surf Spot • Off-Grid Retreat 🌊🌴 Wake up to waves and tropical birds in our cozy Casita, just a 3-min walk from the famous 411 Surf Spot. Between lush rainforest and the Pacific, this off-grid retreat offers adventure and relaxation. Why You’ll Love It Here: Surf in the morning, relax in the hammock by day, and stargaze at night – far from crowds, surrounded by nature.

An open living area is showcased, featuring a comfortable sofa paired with modest coffee tables. Natural light enters through large windows, illuminating the tasteful decor. Visible kitchen and dining spaces can be seen in the background, enhancing the casual yet stylish ambiance.
Guest house in Playa Venao

Modern Casita just a short walk to the beach

Kick back and relax in this calm, stylish space. This newly built casita is 2 bedrooms and 1 bath. It has AC, outdoor shower and a washer and dryer. Relax on your private patio or stroll 2 min to a calm quiet beach. Still only 5 min by car to the heart of Playa Venao and all the surf, restaurants and bars that it has to offer

A private balcony is featured with two woven chairs and a small circular table, providing a serene spot to enjoy views of the lush greenery and ocean in the distance. Natural wood railings frame the space, contributing to the tranquil atmosphere.
Guest house in Playa Venao

Grateful Casita

Take it easy at this unique and tranquil getaway after a day of surfing or exploring. This is a separate casita on my property in a gated community 5 minute drive from Playa Venao. There is a shared small pool. The casita has a small kitchenette area, outside sink and shower, loft with full bed and the best view in Venao!

Popular amenities for guest house rentals in Los Santos Province