
Guest house holiday rentals in Los Santos Province
Find and book unique guest house rentals on Airbnb
Top-rated guest house rentals in Los Santos Province
Guests agree: these guest house rentals are highly rated for location, cleanliness and more.

A Remote Paradise in nature - Ocean View
'Tres-Palmas' sea and nature at its best! A remote hideaway on the Pacific Coast of Panama, but yet close enough to nearby towns and entertainment, Tres Palmas is the perfect place for an invigorating holiday. It is more than just a place to stay, we offer our guests personalized attention through fully equipped facilities and services for your comfort and well being. We enjoy getting to know our guests, sharing life stories and greeting you with an authentic smile for an unforgettable stay.

Cozy & quiet cabin in Cañas
It is a cozy one-bedroom unit, with a closet, a bathroom with separated toilet area, a porch and a rancho. Nestled amidst the serene hills of Canas, the property offers a tranquil retreat with a picturesque ocean view. Wake up to the enchanting melodies of howler monkeys and local birds, immersing yourself in the beauty of nature every morning. While the cabana doesn’t have its own kitchenette, fret not! You’ll have access to a nearby fully equipped community kitchen, shared between 2-3 people.

Ginger Apartment/House for a violinist
Relájate en esta escapada única y tranquila en un barrio privado. A solo 5 minutos a pie hasta la playa, desde la casa puedes escuchar el agua de la quebrada y el canto de los pájaros en los árboles, disfrutar de la naturaleza y la paz que brinda el entorno. El alojamiento dispone de una gran terraza con área de barbacoa, baño y ducha externa y, descendiendo, un deck al borde de la quebrada. Ideal para los amantes de la naturaleza, trabajo remoto, surf, yoga, meditación, caminatas y pesca.

Tiger Beach Cottage @ Los Buzos
A relaxing getaway right across the beach for anyone looking for time in paradise. Located at Los Buzos Resort and its world famous fishing & adventure lodge where guests have direct access to the many activities and amenities it has to offer like its 400 acre private nature reserve Parque Los Buzos where guests can experience the lush Panamanian wilderness and wildlife on more than 40k of trails. Los Buzos has many thrilling activities waiting. We live where the adventure is.

A beautiful beachfront guest house
A perfect jungle-ocean sanctuary in Playa Venao, right across from the main surf point. Open views of the ocean and jungle, tropical vibes, one minute from the surf break and a short walk to town—secluded enough for peace, but close enough to enjoy the action, especially during Venao’s legendary festival weekends. Venao’s green season (roughly May–December-ish) is stunning—nature at its peak. And from around July to October-ish, you can literally watch whales from bed, daily.

Country House with Pool in La Enea de Guararé
Far from the capital city, come to enjoy Panamanian folklore in a rustic but cozy space living a native experience. Lounge in the pool or lounge in a hammock, breathe fresh air, close to the ocean, surrounded by wide, natural gardens for a good walk. Close to the Puerto de Guararé where you will enjoy the best seafood and drinks or enjoy the heart of the best folklore event highlighting the traditions and the best Panamanian chickens.

Accommodation in Las Tablas
Enjoy the simplicity of this quiet and central accommodation. Just a 10-minute walk from Las Tablas village center, birthplace of Panamanian culture and folklore with its activities and festivities. It offers the basic services for short stays. The owner can provide information to the guest to visit nearby beaches and indicate means of transportation to visit nearby districts such as Pedasí and activities of interest in the province.

La Casita del Abuelo
This private place with full private bathroom is perfect for solo adventurers or a couple, seeking peace and relaxation in an authentic environment near the beach and town. This cute hideaway is located minutes’ walks from town and bus stop and about two miles from the nearest beach. It is a new, very clean, private, secure place, and it includes private use of an adjacent bohio with hammocks, barbecue grill, and bar.

"La Jungla" Cabaña close to the beach
New room with shared kitchen and private bathroom close to the beach. You can enjoy all that Cambutal has to offer from this place. It has easy access so you dont need 4x4. Its located 500m from the beach, or 5 mins walking. The room has its own little green area and a large bathroom in the back. We try yo be close to nature and have a cool community here. We are happy to welcome new comers and old faces to Cambutal :)

Casita Verde 411
Ocean View Jungle Casita • 500 m from 411 Surf Spot • Off-Grid Retreat 🌊🌴 Wake up to waves and tropical birds in our cozy Casita, just a 3-min walk from the famous 411 Surf Spot. Between lush rainforest and the Pacific, this off-grid retreat offers adventure and relaxation. Why You’ll Love It Here: Surf in the morning, relax in the hammock by day, and stargaze at night – far from crowds, surrounded by nature.

Modern Casita just a short walk to the beach
Kick back and relax in this calm, stylish space. This newly built casita is 2 bedrooms and 1 bath. It has AC, outdoor shower and a washer and dryer. Relax on your private patio or stroll 2 min to a calm quiet beach. Still only 5 min by car to the heart of Playa Venao and all the surf, restaurants and bars that it has to offer

Grateful Casita
Take it easy at this unique and tranquil getaway after a day of surfing or exploring. This is a separate casita on my property in a gated community 5 minute drive from Playa Venao. There is a shared small pool. The casita has a small kitchenette area, outside sink and shower, loft with full bed and the best view in Venao!
Popular amenities for guest house rentals in Los Santos Province
Family-friendly guest house rentals

A beautiful beachfront guest house

Country House with Pool in La Enea de Guararé

Apartment-house in Herrera

Bedroom, kitchen, bathroom and terrace

Villa Cristina 2

A Remote Paradise in nature - Ocean View

Ginger Apartment/House for a violinist

"La Jungla" Cabaña close to the beach
Guest house rentals with a patio

Casa Pesca

Catch & Relax Cottage @ Los Buzos

Catch & Relax Cottage + Detached Room @ Los Buzos

Tiger Beach Cottage + Detached Room @ Los Buzos

Las Tablas House

Casa Pesca

Tranquility and Peace

Casa Pesca
Other guest house holiday rentals

A beautiful beachfront guest house

Country House with Pool in La Enea de Guararé

Apartment-house in Herrera

Grateful Casita

Bedroom, kitchen, bathroom and terrace

Villa Cristina 2

A Remote Paradise in nature - Ocean View

"La Jungla" Cabaña close to the beach
Destinations to explore
- Rentals with outdoor seating Los Santos Province
- Pet-friendly rentals Los Santos Province
- Smoking-friendly rentals Los Santos Province
- Apartment rentals Los Santos Province
- Hotel rentals Los Santos Province
- Rentals with a hot tub Los Santos Province
- Waterfront rentals Los Santos Province
- House rentals Los Santos Province
- Bed and breakfasts Los Santos Province
- Beachfront rentals Los Santos Province
- Family-friendly rentals Los Santos Province
- Rentals with a patio Los Santos Province
- Rentals with a firepit Los Santos Province
- Rentals with an accessible-height bed Los Santos Province
- Flat rentals Los Santos Province
- Rentals with pools Los Santos Province
- Rentals with a washing machine and dryer Los Santos Province
- Rentals with beach access Los Santos Province
- Villa rentals Los Santos Province
- Guest house rentals Panama