House holiday rentals in Santee

Find and book unique houses on Airbnb

Top-rated house rentals in Santee

Guests agree: these houses are highly rated for location, cleanliness and more.

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Guest favourite

Home in Hanahan

5 out of 5 average rating, 9 reviews

Exquisite Newly Built 2204 sq ft End Unit Townhome

A highest level of hospitality. A 4.94 rating Super host from NJ makes this new townhouse available in SC. It offers multiple levels to relax, spread out. Perfectly located 20 min. from Charleston and only 10 min. from Park Circle, Ideal balance of convenience and serenity. The residence features a luxurious, high-quality elegant furniture and mattress, ensuring a restorative night’s sleep. A spacious balcony and privately fenced turf yard, perfect for unwinding. Depart with treasured memories

Guest favourite

Home in Cayce

4.91 out of 5 average rating, 147 reviews

Columbia’s Best Airbnb

Take it easy at this unique and tranquil getaway. Our Airbnbs are the nicest in each town. From our known luxurious mattresses to the best kept secret… 3D luxury digital Massage chairs relax you from any stressful situation. See why we are ambassador Airbnb host. Stay at this location and you are 5 to 10 minutes to the USC baseball, basketball and Football. Campus is same. Airport is 4 miles. Great kid activity at EdAdventure kid museum. I 26, I-77 and downtown Columbia are minutes away. G

Guest favourite

Home in Summerville

4.9 out of 5 average rating, 140 reviews

Paramour: huge yard home w ground floor bedroom

Fall in love at the Paramour! This Summerville home has everything: +minutes from Nexton, Taco Boy, Nexton Halls Chop House +$0 dollar cleaning fee & professionally cleaned +free early luggage drop +free early check in (when possible) +HUGE fenced in yard +pool/gym access (extra cost) +25-30 minutes to downtown Charleston and beaches like Sullivans Island +VERY safe area +friendly cancellation policy +chore-less check out Cancel your trip within 5 days of arrival and get a full refund!

Top guest favourite

Home in Moncks Corner

4.99 out of 5 average rating, 135 reviews

Your home away from home in Pinopolis

Nestled at the end of a quiet cul-de-sac, this house is close to Lake Moultrie & the Cooper River. It’s also very close to popular wedding venues: Somerset Point, Pineland Village, & Old Santee Canal Park. Moncks Corner Recreational Complex, where many tournaments are hosted, is also about 3 miles away. Pinopolis is less than 20 miles from Summerville & the Volvo area, 40 miles from coastal beaches, and just 45 minutes away from Downtown Charleston. It’s a great location for work or play!

Top guest favourite

Home in Sumter

4.97 out of 5 average rating, 116 reviews

The Parkside Retreat

Welcome to our beautiful Airbnb! Located next to a serene and picturesque park, our home is perfect for families or groups looking for a comfortable stay. With two king master suites and a cozy kids room, we can accommodate up to 6 guests, making it an ideal choice for a family or a group getaway. Each master suite features a comfortable king-sized bed, plush linens, and ample storage space providing a tranquil retreat after a day of exploring the local attractions. Book your stay today!

Guest favourite

Home in Lexington

4.97 out of 5 average rating, 154 reviews

Lakefront home on Lake Murray with private dock

Lakefront home on Lake Murray in Lexington, SC on over 1/2 an acre, 166 feet of waterfront with deep water, private dock, and entertainment space- perfect for an unforgettable vacation or weekend. Entire home for rent-4BR, 3 Bath +2 half baths, 2 sofa sleepers, sleeps 12. Breathtaking kitchen & large living space, perfect for the entire family. 2 single person kayaks, outdoor grill, 65 inch and 55 inch TV, washer/dryer, and fast wifi. Master suite with a lavish bathroom and soaking tub.

Guest favourite

Home in Summerton

4.97 out of 5 average rating, 148 reviews

Luxurious Lakefront Log Home W/Pool & hot tub

Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

Guest favourite

Home in Summerville

4.92 out of 5 average rating, 102 reviews

Guest House/Villa

Enjoy your stay at this immaculately designed new build Villa. Located on a family property surrounded by 2 acres of trees, in a quiet rural neighborhood. Lots of privacy, peace and quiet, yet only 5 minutes from restaurants and stores. 15 minutes from Downtown Summerville, 40 minutes from Charleston and various coastal attractions. The villa is separate from main house and has no shared space other than the driveway. NO smoking, No pets. Laundry service available for long stays.

Guest favourite

Home in Ladson

4.9 out of 5 average rating, 29 reviews

Charleston King Suite Hot Tub Fire Place Patio 1

👍PRIME CENTRALIZED LOCATION to explore all Charleston has to Offer! ✅ NO Cleaning Fees! ✅ 2 mins to Summerville Medical Center ✅ 9 mins from I26 ✅ 35 mins from downtown Charleston and beaches🏖 ✅ 10 mins to Airport/Convention Center/Performing Arts ✅ 3 mins from Publix Grocery and many restaurants ✅ Hot Tub 💦 ✅ King Suite ✅ Covered Picnic Table ✅ Weber gas 🍔 Grill ✅ Fire🔥Place ✅ Fire Pit ✅ High Chair & Pack n Play 🍼 ✅ Foosball Table ✅ 3 Smart TVs 📺 ✅ K cup/Coffee PotTea ☕️

Superhost

Home in Ladson

4.9 out of 5 average rating, 166 reviews

Charleston HotTub FirePit FirePlace Patio Hammock

👍PRIME CENTRALIZED LOCATION to explore all Charleston has to Offer! ✅ NO Cleaning Fees! ✅ 2 mins to Summerville Medical Center ✅ Featured in Relative Race Reality TV show! ✅ 10 mins from I26 ✅ 35 mins from downtown Charleston and beaches🏖 ✅ 18 mins to Airport/Convention Center/Performing Arts ✅ 3 mins to Publix Grocery/restaurants ✅ Hot Tub 💦 ✅ Fire🔥Pit ✅ BBQ 🍔 Grill ✅ Fire🔥Place ✅ Hammock 🌴 ✅ High Chair & Pack n Play 🍼 ✅ Air Hockey Table 🏒 ✅ K Cup/Coffee Pot ✅ EV plug

Guest favourite

Home in Summerton

4.83 out of 5 average rating, 108 reviews

Perfect family vacation retreat at Lake Marion, SC

Great family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. This is the complete family reunion location! We purchased our lake home, built in 1980, in 2009 and began renovation. We updated the kitchen and baths, plus new carpet, tile, windows, appliances, and a complete update to the exterior with new landscaping. We also replaced the dock and the seawall. It has been a journey and we hope you love our house as much as we do!

Superhost

Home in Goose Creek

4.83 out of 5 average rating, 168 reviews

Stay near all Chas attractions, quiet comfort with fenced yard!

Luxurious home with Modern features! ✔ Fenced in yard! ✔ Near Airport and Charleston Colosseum (11-12 Miles) ✔ Convenient to shopping, dining, and local attractions! ✔ Fully Stocked Kitchen! ✔ Lightning Fast Wifi! ✔ Games for everyone to enjoy! ✔ Washer and Dryer on site! ✔ BBQ ✔ Near the Beach? 35 minutes! ✔ Near downtown Charleston? 30 minutes! ✔ Smart Tvs! Pets are allowed upon approval for an additional cost of $25 per pet and a possible $500 refundable damage deposit.