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Vacation rentals in Defiance

Vacation rentals in Defiance

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Defiance

Guests agree: these stays are highly rated for location, cleanliness, and more.

Treehouse Day Spas Penthouse in the Trees
SUPERHOSTPrivate room · 2 guests · 1 bed · 1 private bathroom
Treehouse Day Spas Penthouse in the Trees

VERY SECLUDED ---- SUPER CLEAN ---- NO PETS ------ The treehouse is nestled in the hickory trees on three wooded acres in Dardenne Prairie/O'Fallon area of Missouri. Enjoy a relaxing stay in a private bedroom located in the treetops. The private back porch overlooks the wooded area and is a beautiful place to sit and relax.. GENEROUS DISCOUNT FOR LONG TERM RENTALS.

What guests are saying:

“David is the most gracious host and the treehouse is so lovely! It's peaceful and spa like. You feel as if your off the beaten path but your very close to stores and restaurants. There's a beautiful walking trail behind the treehouse and the upstairs deck is a wonderful place to sit with a coffee or glass of wine. We've stayed in the treehouse twice and plan to return.”

Private guest bedroom 2 in Charlestowne
SUPERHOSTPrivate room · 2 guests · 1 bed · 1.5 shared bathrooms
Private guest bedroom 2 in Charlestowne

You will stay in a private guest bedroom of the three-bedroom house in St. Charles. The house is new, clean, and modern. It locates in the great Charlestowne neighborhood that is quiet, safe, and well-kept. 5 mins to New Town, 10 mins to Historic St. Charles Mainstreet and Katy Trail, 14 mins to I-70, and 20 mins to the airport.

What guests are saying:

“What an amazing host! Tran is super nice and had accommodated my needs no problem. I will definitely stay here if I am ever back in the STL area. 10/10 recommended, no hesitation.”

Red Mule Ranch - Breakfast included
SUPERHOSTEntire guest suite · 2 guests · 1 bed · 1 bathroom
Red Mule Ranch - Breakfast included

Cozy, rustic, “bunkhouse,”w/charming cedar log double bed. Private bath. Located on 85 acre horse farm. Large pond, beautiful pastures. Near Innsbrook , Cedar Lakes Cellars Winery, Big Joel's Safari, Long Row Lavender Farm, and many other local wineries and antique shops. Homemade breakfast (5 choices), at no extra charge, and chocolate chip cookies are in your room upon arrival. Perfect anniversary get away. Your favorite pie or cake for two can be arranged for a small charge. Contact me.

What guests are saying:

“Red Mule Ranch, a true beauty just outside of Saint Louis. Donna and her husband Lloyd take so much pride in their property and in taking care of their customers. You instantly feel at home here. The space and grounds were SPOTLESS and Donna was so polite and accommodating. No detail was missed. The bunkhouse has everything you could need, fresh towels, toiletries, hair dryer, phone chargers, card games, coffee maker, etc. When exploring the ranch you’ll find the chicken coup, beautiful lake stocked with cat fish, rolling hills where the deer graze, an ideal fire pit setup with all the supplies for fireside fun, of course, there are horses and a 40 YEAR OLD RED MULE. Upon arrival Donna gave us a quick lay of the land and took our breakfast orders for the morning. 9am we stepped out onto the porch and there it was all setup and ready on the table complete with fresh wildflowers. This place is an excellent choice for a getaway with just enough modern comforts. We loved it!”

Holiday rentals for every style

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Popular amenities for Defiance holiday rentals

  • Kitchen
  • Wifi
  • Pool
  • Free parking on premises
  • Air conditioning

Other great holiday rentals in Defiance

Beautiful sanctuary guesthouse
SUPERHOSTEntire guest house
Beautiful sanctuary guesthouse
Price:₹11,563 / night
Escape to a relaxing hideaway nestled in trees.
SUPERHOSTPrivate room
Escape to a relaxing hideaway nestled in trees.
Price:₹2,691 / night
Lovely private apartment in historic home
SUPERHOSTEntire flat
Lovely private apartment in historic home
Price:₹5,606 / night
Private Luxury Suite 2 Blocks From Main Street
SUPERHOSTEntire flat
Private Luxury Suite 2 Blocks From Main Street
Price:₹5,509 / night
Uncle Eddie's Camper
SUPERHOSTPrivate room
Uncle Eddie's Camper
Price:₹3,385 / night
Hillside Cabin on 43 Acres w/ Private Lake & View!
Entire cabin
Hillside Cabin on 43 Acres w/ Private Lake & View!
Price:₹16,614 / night
Clean & Cozy Bedroom in a Quiet Neighborhood
SUPERHOSTPrivate room
Clean & Cozy Bedroom in a Quiet Neighborhood
Price:₹972 / night
RELAXING Innsbrook Chalet LakeResort W of St Louis
Entire chalet
RELAXING Innsbrook Chalet LakeResort W of St Louis
Price:₹14,884 / night
Squirrel Run at Innsbrook Resort
SUPERHOSTEntire cabin
Squirrel Run at Innsbrook Resort
Price:₹10,037 / night
Private Suite in Nice Home with a view! Near I-70
SUPERHOSTPrivate room
Private Suite in Nice Home with a view! Near I-70
Price:₹3,267 / night
Innsbrook Chalet - Newly Renovated, Lakeside
SUPERHOSTEntire chalet
Innsbrook Chalet - Newly Renovated, Lakeside
Price:₹18,685 / night
Private Walkout w/ 1 King Bed/1Bath + Living Room
Private room
Private Walkout w/ 1 King Bed/1Bath + Living Room
Price:₹4,410 / night
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