
Holiday rentals in Commerce Township
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Top-rated holiday rentals in Commerce Township
Guests agree: these stays are highly rated for location, cleanliness and more.

Cape Charm: 3 BR Close to SEMO & Mercy! CLEAN!
Cape Charm is a "charming" 3 BR home in a safe, quiet neighborhood perfectly located next to SEMO, Mercy Hospital, Capaha Park & the historic district - all less than a 7 minute walk! Feel at home in a magnificently cute 3 bedroom home (w/king bed), fully equipped kitchen, living room, dining room, bathroom, & sun room. Free, fast WIFI, a smart TV in the living room & bedroom. It's centrally located to everything! We are experienced hosts with highly rated listings in Florida and Missouri.
4.86 out of 5 average rating, 57 reviews
Brand new 2 bedroom unit right in downtown Cape.
This special place is close to everything, making it easy to plan your visit. Walking distance to restaurants, the river and nightlife. Property includes wifi, full kitchen, laundry, deck and private parking for one. One king bed room and a twin bed room in addition to a roll out twin bed along with a 60 inch smart television. Dog bed and bowls included along with board games! Property is conveniently located across the street from "The Bar" the famous spot from the movie "Gone Girl" .
4.95 out of 5 average rating, 325 reviews
RiverSide Barn Suite on the Mississippi River.
The barn suite is a beautiful 2 bedroom apartment overlooking the Mississippi River and housed in a unique barn with its own separate entrance. The deck views are spectacular and takes sitting and relaxing to a new level. Our wine place “The RiverHouse “ is within walking distance with the best worldwide wines and menu in the area. www.theriverhousewineplace.com We are 12 minutes from Cape Girardeau and serviced by Lyft & Car-Go. You May contact us by text or call and available at any time.
4.96 out of 5 average rating, 53 reviews
Twisted Sassafras Treehouse
A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!
5.0 out of 5 average rating, 217 reviews
Private Treehouse Retreat | Hot tub
The TreeLoft is the first of two treehouses at BaseCamp—designed for cozy seclusion, romance, and rest. Nestled in a private forest just 1 hour from St. Louis, it blends upscale comfort with immersive nature, while still being 20–35 minutes from hiking, wineries, and dining. ✨Our NEW treehouse, The TreeRise, offers an even more elevated, spacious experience at BaseCamp. Perfect for romantic getaways, anniversaries, personal retreats, and intentional escapes to unplug and reconnect.
5.0 out of 5 average rating, 722 reviews
Under the Stars - Farmhouse
Enjoy the tranquility of this modern farmhouse charmer! Custom built minutes from downtown Cape. Relax outside around the fire pit, roast marshmallows and watch the sunset. Finish the night with a long soak in the hot tub. Start the morning on the front porch rocking chairs and take in a sunrise. Open concept, fully equipped kitchen, 3 Bd. including King master/full bath, 2 Queens with full guest bath. Near Trail of Tears and walking distance to classic dive bar/burger joint
4.94 out of 5 average rating, 288 reviews
Downtown Guesthouse- Romantic Getaway
The guesthouse seamlessly blends modern amenities with historic charm in a cozy, compact space. The antique claw foot tub/shower combo offers a charming, yet snug, spot for a relaxing soak—true to its historic roots, the bathroom could be best described as a quaint water closet. After a day of exploring unwind in the patio. Play a favorite record, and savor your coffee while daydreaming about new experiences. Despite its small size, it provides all the modern comforts you need.
4.94 out of 5 average rating, 617 reviews
The Wooded Walnut House
Escape to our charming home nestled among majestic walnut and oak trees on a spacious lot in Cape Girardeau! We've created a welcoming retreat that combines the tranquility of nature with unbeatable convenience - complete with a lovely deck and patio for outdoor relaxation - just minutes from historic Downtown Cape Girardeau, Southeast Missouri State University, and Capaha Park (home of SEMO and Cape Catfish Baseball).
5.0 out of 5 average rating, 84 reviews
Newly Renovated 3 Bedroom 2 Bath Home - Sleeps 9
Looking for a spacious and welcoming Airbnb in Sikeston? 🏡✨ This gorgeous, newly renovated 3 bedroom, 2 bathroom home is the ideal destination for unforgettable memories with your loved ones. The house sleeps up to 9 guests comfortably, making it perfect for families and groups. Conveniently located in a fantastic residential area, you're just moments away from local attractions, shopping, and dining spots.
4.97 out of 5 average rating, 31 reviews
Spacious Rural Retreat
READ ENTIRE DESCRIPTION BEFORE BOOKING!!! Retreat in this spacious home, tucked into a quiet natural setting. The second story deck extends the full length of the front of the house, giving a lovely view of the peaceful surroundings. With no television or other technological distractions on the premises, this home is perfectly suitable for quality time with your loved ones and can accommodate large families.
4.97 out of 5 average rating, 198 reviews
The Hamilton House
Majestic, Two Story Home. A Great Place for Making Memories. BEFORE YOU BOOK: So there are no misunderstandings. Please read our rules, and understand our pricing, because there is an extra guest fee after the first 2 guests and weekends are priced different than weekdays. 2 Night Min. Stay on Weekends Only - 1 Night Stays Sun. - Thurs. No Parties-No Smoking-No Animals
4.98 out of 5 average rating, 456 reviews
The Brick Home
Single-story, charming brick home. 1.2 miles from Southeast Missouri State University and The Mercy Hospital. 1.9 miles from the St. Francis Medical Center. Great peaceful neighborhood for a short or long-term stay. 65-inch TV in the living room | Washer & Dryer is conveniently located in the basement. Pets allowed with an extra fee.
4.9 out of 5 average rating, 31 reviewsPopular amenities for Commerce Township holiday rentals
Other great holiday rentals in Commerce Township

Beautiful Sunset Cottage with amazing views
4.94 out of 5 average rating, 32 reviews
Newly Renovated Farm House Overlooking 5 Acre Lake
5.0 out of 5 average rating, 53 reviews
Gorgeous 1856 Log Cabin, Completely Renovated
4.82 out of 5 average rating, 56 reviews
Entire Cottage Nestled in the Woods
5.0 out of 5 average rating, 84 reviews
Enchanted Mermaid A-Frame | Creek | Pet Friendly
4.98 out of 5 average rating, 55 reviews
Relax Here! off Broadway
5.0 out of 5 average rating, 13 reviews
Runway Retreat
5.0 out of 5 average rating, 3 reviews
Updated Farmhouse w/ King Suite
4.93 out of 5 average rating, 60 reviewsDestinations to explore
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