Guest house holiday rentals in Anderson County

Find and book unique guest house rentals on Airbnb

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Popular amenities for guest house rentals in Anderson County

Family-friendly guest house rentals

Top guest favourite
Guest house in Liberty
4.93 out of 5 average rating, 197 reviews

Holly Hideaway! 10 Highway miles to Clemson U!

RittaRating, 5 stars1 month ago
Jen’s Hideaway is the perfect private spot to come back to after visiting Central and Clemson. It is extremely clean and well appointed. The bed is very comfortable. Jen is a friendly host. She even baked us delicious blueberry muffins.
Guest favourite
Guest house in Pendleton
4.89 out of 5 average rating, 264 reviews

La Bella Farm

BrandonRating, 5 stars3 weeks ago
Had an amazing time at this gorgeous space. It was exactly as advertised, and Jessica was extremely responsive and proactive as a host. Thank you so much! Will definitely book there again!
Top guest favourite
Private room in Pelzer
4.98 out of 5 average rating, 129 reviews

South Oaks Guesthouse

MelissaRating, 5 stars6 days ago
Diane’s home is lovely! T It was relaxing, comfortable and welcoming! We will stay again!
Top guest favourite
Guest house in Donalds
4.99 out of 5 average rating, 378 reviews

Home on the farm

SandraRating, 5 stars2 weeks ago
OMG I can not express enough the peacefulness and how wonderful this place is . Mrs. Ruth and Mr. Bob are so sweet . It was exactly what I was looking for. Sitting out on the screened porch with coffee in the morning you can hear the birds it was wonderful. The rental was very well kept and very clean . I will definitely want and will be going back. Thank you Mrs. Ruth & Mr. Bob for a wonderful time.
Guest favourite
Guest house in Townville
4.86 out of 5 average rating, 257 reviews

Lisa’s Lodge

AnnemarieRating, 5 stars2 weeks ago
Lisa's Lodge was wonderful; just perfect for the two of us. It was so nice to take a dip in the lovely pool, sit by the the beautiful lake and take walks around the grounds and up the road. Proximity to Anderson yielded a couple of good restaurants and it was also an easy trip to Greenville and its charms. Lisa is very nice and her son offered help in case we needed it during a rainstorm. What a happy experience! We both want to go back!

Guest house rentals with a patio

Top guest favourite
Guest house in Seneca
5 out of 5 average rating, 35 reviews

One Particular Cove ... on Lake Hartwell

JohnRating, 5 stars1 month ago
We couldn’t be happier with our stay. Perfect size for the 4 of us. Ginny and Sid are wonderful hosts. Our flight was changed and delayed and we didn’t arrive till 3am and had to leave for Clemson graduation by 730am. With little to no time to sleep or eat breakfast they stocked the place with fresh pastries, fruit and bagels and cream cheese. We sadly were only to spend nights at the property so we did t get a chance to take the whole lake location in. I’d go back in a heartbeat
Top guest favourite
Guest house in Townville
5 out of 5 average rating, 26 reviews

Charming Waterfront Guest House

SteadmanRating, 5 stars1 week ago
Beth’s place is amazing. We have stayed here before and loved it so much we came back to stay again. It’s a beautiful house on the water with a pristine guest house that’s private, extremely clean, and very well maintained. Beth is incredibly friendly and always a great communicator. Would highly recommend, 10/10. Thanks Beth!
Top guest favourite
Guest house in Clemson
5 out of 5 average rating, 44 reviews

Downtown Clemson Guest Suite!

ChristinaRating, 5 stars1 month ago
The studio was adorable! Great location, clean, new and perfect for our stay in Clemson. There were only two of us but, plenty of room. I only wish I had found it before graduation. I will definintely look to reserve again when we head down for games. Great communication from Casey!
Top guest favourite
Guest house in Clemson
5 out of 5 average rating, 23 reviews

Adorable Cottage 2 mi. from Death Valley

AmyRating, 5 stars1 month ago
Clean, peaceful, great location to the campus. Hosts are friendly and kind. My second stay and I can’t wait to go back.
Top guest favourite
Guest house in Honea Path
4.91 out of 5 average rating, 47 reviews

The Honey Flat

RaymondRating, 5 stars1 day ago
Absolutely perfect! Everything looks and smells brand new!
Top guest favourite
Guest house in Central
5 out of 5 average rating, 16 reviews

Vacation Home Clemson and Lakes

AnnRating, 5 stars1 month ago
We had a wonderful stay in this beautiful home for our Tiger's graduation from Clemson. The home was extremely clean and well stocked with everything we needed. We enjoyed the backyard and patio as well. The host was friendly and responsive.
Guest favourite
Guest house in Piedmont
4.99 out of 5 average rating, 96 reviews

Shou-Sugi-Ban Retreat on the Saluda River

Carolyn WinnieRating, 5 stars1 week ago
Surprise last minute Father’s Day mountain get away for my husband. This home was perfect for the three of us. Adorable, Clean and a spa shower! We enjoyed hanging on the deck with our dog listening to the river rapid (minus some traffic noise) and just chilling all night and morning! Delicious coffee! Quick trip home to the beach rested and grateful for unplugging! We would certainly would love to come back! **The lightning bugs were a huge bonus!
Top guest favourite
Guest house in Seneca
5 out of 5 average rating, 17 reviews

Quin's Lake House, Keowee. Private bottom Floor.

EmmaRating, 5 stars2 months ago
This is a beautiful place to stay on the water. Owner is continuing to make updates to make the stay easier particularly in the kitchen area.

Guest house rentals with a washing machine and dryer

Guest favourite
Guest house in Pelzer
4.96 out of 5 average rating, 72 reviews

Quaint guest cottage in Upstate

DeborahRating, 5 stars1 week ago
Not our first stay at The Canning House and not our last! We love the country feel and the rain on the tin roof. It was so nice to wake up and see the cows out back in the pasture (took some pics there) and hearing the birds chirping. See you another time for sure!
Guest favourite
Guest house in Seneca
5 out of 5 average rating, 6 reviews

The Cottage at Keowee Hollow

CandaceRating, 5 stars1 month ago
We absolutely love The Cottage. It was close enough to my grandson’s graduation festivities in Clemson. It was so clean and private and we will definitely use it again on our next trip to the area.
Guest favourite
Guest house in Townville
5 out of 5 average rating, 10 reviews

Paradise Point on Lake Hartwell

LoriRating, 5 stars1 week ago
This place really is a Paradise! The dock and the area by the lake are amazingly pretty and peaceful. We enjoyed fishing (caught brim and catfish), sunbathing, and relaxing by the water. We brought our own boat and that went really well. The boat launch was nearby and we were able to take the boat to a fun restaurant called The Grill. The guesthouse was clean and cozy. We had 7 adults and there was plenty of room. The rec building gave some extra space to hang out, play ping pong, and watch a movie. The guys enjoyed playing basketball and pickle ball on the outdoor court. The kitchen had all of the basics and we used the outdoor gas grill. Overall it was just a really fun family weekend at the lake and we would definitely recommend this place!
Guest favourite
Guest house in Clemson
4.9 out of 5 average rating, 20 reviews

Clemson Carriage House - NEW!

TylerRating, 5 stars1 month ago
Ashley‘s carriage house was such a cute place to stay. It is very central in Clemson to everything you would need to go to and was perfect to attend an event in Clemson. Is extremely clean and I especially loved all the Clemson Tiger touches in decor. I would stay here again if I came back for a Clemson game!
Top guest favourite
Guest house in Seneca
5 out of 5 average rating, 27 reviews

Hartwell Hideway

HannahRating, 5 stars1 day ago
What a perfect little place! We've stayed at lots of Airbnb's and Hartwell hideaway was among the best. Right on the lake with a great dock and fire pit next to the lake. The apartment was spotless and very comfortable. At night it was quiet and dark, made for great sleeping!
Guest house in Townville
4.67 out of 5 average rating, 6 reviews

Beautiful Luxury home on Lake Hartwell by Clemson

BradyRating, 5 stars34 months ago
Great place & location for peace and sound. Would highly recommend to stay there again.
Top guest favourite
Guest house in Clemson
5 out of 5 average rating, 22 reviews

Riggs Drive Gameday Getaway

SteveRating, 5 stars1 month ago
Really nice space walkable to downtown but on a quiet street. The space looks brand new, well designed and appointed. High ceiling ls and very open feel. Everything is high quality and very clean. We will definitely stay here when in the area

Destinations to explore