Hotel holiday rentals in Saint Charles County

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Top-rated hotel rentals in Saint Charles County

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Guest favourite

Hotel room in St. Louis

4.74 out of 5 average rating, 76 reviews

The West End by Cortex, Forest Park, BJC & Zoo

Welcome to The West End, your ideal retreat in the heart of the Central West End! Just steps away from charming attractions like forest park. Great amenities are: - Fast and stable fiber internet connection - Communal kitchen with 2 sets of range, ovens, fridges, microwaves, and dishwashers. - Complimentary coffee - Secured Gated Parking $10/Night - Hot Tub - Great patio space with seating and a gas grill - Complimentary Netflix, Hulu, Disney+, and ESPN+, where available and local TV channel

Superhost

Hotel room in St. Louis

4.9 out of 5 average rating, 130 reviews

Chic Ultramodern Studio Loft w/ Designer Features

The Nash Loft is a stunning minimalist studio with 12’ ceilings, a fully-equipped kitchen with black stainless appliances and quartz countertops, a spacious walk-in closet, stackable washer + dryer, a designer bathroom with black stainless fixtures and frameless glass shower, and bright 7’ industrial steel-frame windows with views of the tree-lined street and shops below. Situated along the famous Locust Street in the heart of Midtown, you’ll be steps from SLU, Wells Fargo, BJC, and the Grove.

Guest favourite

Hotel room in Alton

4.95 out of 5 average rating, 41 reviews

Three Bedroom River View Guest House-3 Bathrooms

An escape from the ordinary in our River view guest house. On bottom level is an art glass shop offering classes in stained , fused, and mosaic art glass you may partake in at an additional cost. Bicycle built for two available for cycling the national scenic byway. Walk to shops, casino, restaurants, breweries, and concerts. Cruise ship dock is 1/2 mile away. Extend your stay before or after to enjoy taking a stained glass class offered in our shop below as a souvenir of your trip.

Top guest favourite

Hotel room in St. Louis

4.98 out of 5 average rating, 44 reviews

Luxury Retreat, Hot Tub,En-Suite Bath, Location+

Discover refined elegance in The Riverfront Suite, where Gothic grandeur meets contemporary comfort. This distinctive retreat showcases original stained glass windows and exotic wood finishes . A plush queen bed and ambient electric fireplace create an intimate atmosphere, while the luxurious en-suite bathroom features heated floors, designer tile work, and a 2-person soaking tub. Take in panoramic city views from the shared rooftop hot tub. Perfect for couples seeking a romantic escape.

Superhost

Hotel room in Brentwood

The Best of Suite Living! Ideal for Work & Leisure

By staying at our property, you can make the most of your trip, whether it's for work or pleasure. We are conveniently located near renowned destinations including Hanley Park, the St. Louis Children's Aquarium, and Oak Tree Park in the Brentwood neighborhood. We are close to Whole Foods Market, Applegate's Deli, and Camille's Sidewalk Cafe, among other well-known restaurants. You can grab a free breakfast in the morning and get a head start on your day. Enjoy the free parking and Wi-Fi.

Hotel room in Earth City

4.42 out of 5 average rating, 19 reviews

Home Away From Home | Free Airport Shuttle

The Holiday Inn St. Louis Airport West Earth City is just 6 miles from the St. Louis-Lambert International Airport and offers a complimentary airport shuttle. Conveniently located near downtown St. Louis and Historic St. Charles, travelers and guests will be in an ideal location for shopping, dining, and entertainment. Visitors can dine or enjoy cocktails at Elements, our on-site restaurant and bar. A well-equipped fitness center and a relaxing heated indoor pool complete your stay.

Hotel room in Cottleville

5 out of 5 average rating, 3 reviews

Double Queen Room 203

Room 203 features two queen-sized beds Oak Street Inn & Lounge, 8 Room Boutique hotel situated in the bustling center of downtown Cottleville. Oak Street Inn & Lounge will offer an elegant restaurant and craft cocktail lounge on the ground floor Indulge in room service from Pink Willow Cafe, or dine in! Come up to the rooftop patio on the third level for a cocktails, small bites and breathtaking views of Cottleville. Look for our Hidden Gem the Speakeasy in the lower level!

Hotel room in Saint Charles

4.78 out of 5 average rating, 251 reviews

1st Capitol Mansion Boutique Hotel - Suite 201

This unit is a hotel style unit that is located in the heart of downtown historic St. Charles. It's located right across the street from a coffee shop, wine bar and the oldest local pub in St. Charles. It is just a few blocks away from all of the shopping and restaurants on Main St. The mansion was built in 1902 and still holds all of the charm from back then. This is a private suite with it's entrance from the rear of the building right off the parking lot.

Hotel room in St. Louis

4.8 out of 5 average rating, 5 reviews

Art Galleries All Around + Pet Friendly & Dining

Welcome to Seven Gables Inn ✨ Stay steps from shops, galleries, and top dining in Clayton’s historic district. Just 10 minutes from downtown St. Louis and 15 minutes from Lambert Airport, this boutique hotel blends 1920s Tudor charm with modern luxury. Enjoy elegant rooms, a charming courtyard, complimentary Wi-Fi, and authentic dining at SEVEN restaurant. A timeless St. Louis experience awaits!

Hotel room in Saint Charles

4.54 out of 5 average rating, 13 reviews

The Opulent Owl Suite

The Owl Suite at the Divine Otter Hotel offers a stylish 1-bedroom escape, sleeping up to 2 guests. Enjoy upscale furnishings, a modern design, and a spacious full bathroom with plenty of natural light. Located in the heart of Historic Main Street Saint Charles, you’ll be steps away from shops, dining, and more. This impressive suite is the perfect blend of comfort and location!

Top guest favourite

Hotel room in St. Louis

4.97 out of 5 average rating, 68 reviews

Napoleon's Retreat - Lafayette Room - Lafayette Sq

Lafayette square has the largest collection of renovated victorian houses in America and this is one of them. Dating to 1876, this historic home offers quality amenities. We are located near: America's Center Convention Complex - 2 Miles Bush stadium - 1.5 Miles Stifel Theatre - 1.4 miles Gateway Arch - 2.1 Mi Enterprise Center - 1.2 Mi Delmar Hall - 7 Mi

Hotel room in Clayton

4.91 out of 5 average rating, 11 reviews

Less than 2 miles from St. Louis Galleria Mall

Find us a mile from I-170 and less than two miles from St. Louis Galleria Mall and Washington University in St. Louis. St. Louis Zoo and Forest Park are a 10-minute drive away, while The Pageant on Delmar Loop is a 6-minute drive from our door. Enjoy daily free hot breakfast served daily, a drink at Danielle's Bar, free WiFi, and our indoor mineral pool.