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Mansion holiday rentals in Panama

Find and book unique mansions on Airbnb

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Popular amenities for Panama mansion rentals

Luxury mansion rentals

Superhost
Flat in Panama City
4.71 out of 5 average rating, 283 reviews

Penthouse with rooftop and pool 5 rooms Di5

ObinnaRating, 5 stars1 week ago
Great location, responsive host, with lots of things to do around
Guest favourite
Villa in Bocas del Toro
5 out of 5 average rating, 64 reviews

Casa del Mar - eco aqua villa

EsterRating, 5 stars1 month ago
Julia’s place is an absolute gem, nestled in the calm waters of the Caribbean Sea at the southern tip of Isla Cristóbal—about a 30-minute boat ride from the main island, Isla Colón. From the moment we arrived, we felt like we were stepping into a unique off-grid paradise. The house itself is self-sustaining, powered by solar energy and using filtered rainwater (which, by the way, tastes amazing!). While there’s no air conditioning, there are plenty of fans to keep the air moving. The views from the house are absolutely stunning. In the mornings, dolphins often patrol the area like local marine police, and right beneath the house, we saw massive snappers swimming in the clear waters. If you paddle out into deeper water by kayak or paddleboard, you’ll likely spot graceful rays gliding beneath you—an unforgettable experience. Victoriano, a local caretaker, was extremely helpful on the property and in surrounding areas and guided us on a hike to see the sloths and the monkeys.
Guest favourite
Cottage in Panama City
5 out of 5 average rating, 19 reviews

Hacienda La Perezosa in Cerro Azul

TeddyRating, 5 stars1 month ago
Very well maintained and clean. Perfect spot for a relaxing time with ample amenities and service staff. Will definitely repeat!
Superhost
Villa in Saboga
4.75 out of 5 average rating, 12 reviews

Casa Laguna - luxury beach front house with pool

AmyRating, 5 stars3 months ago
We had an amazing stay! The place was beautiful, remote, surrounded with wildlife, gorgeous beaches, gear to use, great pools. Hosts were always available to answer our questions, give us rides, connect us with boats, fix things that needed fixing. The house space was perfect for our group of 7, including 4 kids! We did bring a bunch of food from the mainland, which was a good idea. Local market is limited and the nice restaurant just down the beach was good but expensive for regular meals. Zully was available to cook for us and her cooking was outstanding! Matthias and his local manager were very helpful and friendly. We had a beautiful experience and the house and surroundings were wonderful. Highly recommended!
Guest favourite
Boat in Río Azúcar
5 out of 5 average rating, 5 reviews

Private Luxury Catamaran

ChizzieRating, 5 stars1 month ago
Oh wow!! What a stay! We had 2 weeks around Costa Rica and Panama for our honeymoon and 3 nights were spent here, definitely the highlight! The boat is so beautifully kept and we were literally sailing in paradise. Anghie and Georgio were incredible and we were never left hungry or without a drink in our hands, be it beer, wine or a simple spirit and mixer. The food was fantastic, super fresh and they catered for allergies. The bed rooms were very comfortable and equipped with fans so even when the A/C turns off (in the middle of the night) you can still keep cool. Every day we were taken to (often) completely uninhabited islands where we could snorkel, paddle board or kayak but we would have been welcome to stay on the boat relaxing in the sun. It was the best way to spend time for our honeymoon, with privacy when we wanted it but also great, friendly company! We were lucky enough to book it for just the two of us but we are already planning our next trip - this time with friends!
Guest favourite
Villa in Rio Hato
4.91 out of 5 average rating, 58 reviews

Luxury 4BR Villa + Guesthouse & Pool @Buenaventura

Elizio (Bo)Rating, 5 stars1 week ago
It is a beautiful villa home in beautiful Buenaventura, Rio Hato. Very nice ammenities in the home with a wonderful backyard and pool as well. Both Philip and his property manager, Olga, were very responsive and helpful when we had questions or concerns. It has a few restaurants and a shoppette inside the resort. There is also a very large Super99 grocery store and others stores a 10 min drive outside the resort. All in all, this was a wonderful property and stay for our 8-member family group. Thank you!
Top guest favourite
Villa in Panamá
4.98 out of 5 average rating, 53 reviews

Breathtaking Views Mansion w/King Beds

PavanRating, 5 stars3 weeks ago
Its a 5 star house. The house is way bigger than what photos suggest. It can easily fit in 10 people. It is in a very safe neighborhood and close to great restaurants and bakery. It also has good India mart close by if you need any Indian provisions. House all the amenities you need. Pool, garage, big grill, nice kitchen, theatre room with pool table and a yoga place. The only part of the house that we could not get to enjoy is the golf area. I wish we had more time at the house. Will definitely recommend the house. Also Bradley was very responsive.
Guest favourite
Home in Bocas del Toro
4.92 out of 5 average rating, 25 reviews

Architectural Waterfront Home - "Casa Comunal"

FrankRating, 5 stars4 months ago
Fantastic place, the sea is your backyard. Monkeys, tracking, squirrels, and surfers on the waves passing by. Great house, minimalist but very nice with various hangouts. Keep in mind that it can be warm in the house and that insects can easily enter....but there is something great about that.

Pet-friendly mansion rentals

Top guest favourite
Villa in Costa Esmeralda
4.97 out of 5 average rating, 95 reviews

#1 Villa with a swimming pool, jacuzzi, pool table, and ping pong.

MarubyRating, 5 stars1 month ago
The truth was excellent the house, they were always attentive to us being comfortable. Everything is clean, I recommend it. It was a wonderful weekend.
Guest favourite
Apartment in El Chirú
5 out of 5 average rating, 23 reviews

Laguna Fun and Sun: Your Escape Awaits

AlyseRating, 5 stars3 weeks ago
The stay was amazing, we enjoyed it from beginning to end, surely our host has experience in hospitality because everything was five stars.
Superhost
Home in Gamboa
4.87 out of 5 average rating, 95 reviews

BirdHouse@ Gamboa Panamá Canal

FrancescaRating, 5 stars2 months ago
What an incredible stay we just had. This is our third time to Panama and our first in Gamboa and it was amazing. The home was gorgeous and spacious. The kid zone was a blast for both kids and adults. We went on a zip lining tour and the boat tour of the canal, monkey island and Embera tribe and they were worth every penny. Our 9-12 year olds felt safe and saw every animal on our wish list. Just an amazing adventure topped off by the privacy of our own home with a gorgeous pool. We just loved it. Thank you so much!!!
Top guest favourite
Flat in Buenaventura
4.99 out of 5 average rating, 102 reviews

Exclusive apartment steps from the sea in Puntarena

MarlaRating, 5 stars1 week ago
Great place to relax with family and friends. Pool and supermarket is within walking distance. Friendly and helpful staff of Buenaventura they will drive around the area.
Guest favourite
Home in Playa Bluff
4.89 out of 5 average rating, 44 reviews

Jungle House 100m from the beach

RiaRating, 5 stars1 month ago
The Jungle House at Playa Bluff was a great getaway destination for our 2 families, with 4 adults and 6 children, ages 4-11. The pool was great and the sleeping arrangements worked well for us. There is a decent kitchen, but we mostly ate at nearby restaurants or on our daily adventures. The house is about a 25 min taxi ride from the main town and the road can get soupy, but any of the truck taxis can easily get to the house. The beach is stunning, although not great for swimming with rip tides and currents. The host was super responsive to all questions and I would highly recommend this house. We even saw sloths and monkeys right around the house.
Guest favourite
Apartment in San Carlos
4.95 out of 5 average rating, 38 reviews

Lovely Beachfront Condo at Ensenada Beach

OmarRating, 5 stars2 months ago
We had a great time during our short stay, quiet beautiful condo with big windows and a great view of the ocean, it was close to markets and fast food restaurants, great location overall, we are sure to return.
Guest favourite
Home in Playa Malibú
4.91 out of 5 average rating, 11 reviews

MoMa Malibu, Beach front

EstebanRating, 5 stars1 month ago
Our stay at this beach house was absolutely wonderful. From the first moment, we felt at home thanks to the warmth and attention to details that are perceived in every corner. The location is unbeatable, with the relaxing sound of the waves as a constant soundtrack and the beach just steps away. We really enjoyed the sunsets from the pool. The house was spotless, very nicely appointed and tastefully decorated. Undoubtedly an unforgettable vacation. Thank you so much for sharing this paradise with us!”
Guest favourite
Home in playa coronado
4.82 out of 5 average rating, 141 reviews

Beach Villa in Coronado.

ElibetRating, 5 stars2 weeks ago
Clarissa was very attentive to us. The house is beautiful.

Mansion rentals with a pool

Guest favourite
Villa in Rio Hato
4.97 out of 5 average rating, 30 reviews

Villa Agueda Decameron, golf club and swimming pool

JeremyRating, 5 stars5 months ago
What a place, one of the better Air B &B’s in Panama, have everything you require, nice pool, cold jacuzzi that works, very amazing stay Annelise, thanks for everything.
Superhost
Villa in Santa Catalina
4.84 out of 5 average rating, 61 reviews

Infinity Pool Boutique Villa on The Point Break

OlgaRating, 5 stars3 weeks ago
We had a great stay. The house has amazing views and a nice pool, and is close to a new hotel where you can walk over to for a drink or food. Pietro was super responsive and helpful and even got us a new fridge when the other one stopped working properly. Highly recommend.
Guest favourite
Villa in San José
4.83 out of 5 average rating, 72 reviews

25% OFF The Family Mini Resort House @Punta Barco

ErikaRating, 5 stars3 weeks ago
Super good place , only that some details were missing, 1 air was not working and the lights of the bathrooms several were burned , but otherwise everything was fine
Guest favourite
Chalet in Las Lajas
4.79 out of 5 average rating, 66 reviews

Front beach exclusive Villa.

ArianaRating, 5 stars2 months ago
Just returned from an incredible stay at Rafael’s beautiful beachfront home in Las Lajas, where we gathered to celebrate my mom’s 70th birthday. The house was perfect for our family—spacious, welcoming, and thoughtfully designed. Four of the five bedrooms had their own private bathrooms, making it easy for everyone to have their own space. The master bath was a dream with its Jacuzzi tub and separate shower, another had a soaking tub and rain shower, and the others featured spa-like rain showers. We enjoyed slow mornings with ocean views, meals in the fully equipped kitchen, and evenings by the pool. Rafael was a wonderful host—responsive and kind. This home helped us create memories we’ll never forget.
Guest favourite
Home in Panama City
4.95 out of 5 average rating, 40 reviews

Nice duplex house with a swimming pool.

MaricelRating, 5 starstoday
Don Gerardo was an amazing host. He picked my family and I up from the airport and welcomed us to his place with a cake which he did not need to do at all. He went above and beyond by offering us advice on local spots and attractions and completely changing the washing machine when the last one had issues. He was very attentive and welcoming to my elderly parents. He even drove my daughter back home from the airport after dropping her off there (one hour round trip) as she had forgotten something important at his place. The house was huge and exactly what my family and I needed. There were no issues at all from the house apart from the aforementioned washing machine which he rectified immediately when we were out of the house. Would definitely recommend to anyone with a big family to stay in Gerardo’s place. He is just an amazing guy and super super host . Highly recommended
Superhost
Chalet in Juan Hombron
5 out of 5 average rating, 4 reviews

Charming house with beach access

GalinaRating, 5 stars3 months ago
Geraldina's house is beautiful and very comfortable, every detail has been taken care of with the utmost affection. The beach is one of the best in the area, suitable for bathing and strolling. But the best part is Geraldina, with her positive attitude, resolution and good energy, always ready to improve the experience and make you feel at home. We recommend this place 100%. We had a fantastic few days.
Guest favourite
Apartment in El Chirú
4.96 out of 5 average rating, 28 reviews

Buenaventura | Luxury Beach Apartment | Panama

RenataRating, 5 stars1 month ago
Our stay in Rapha's apt was spectacular. The apartment is super comfortable to be with a family, it is very well equipped and very clean. They also have details that make you feel at home, like a baby chair, plates, glasses, etc. We loved the place, the apartment and the attention we received from Rapha! We will definitely come back and recommend it 100%.
Guest favourite
Flat in Panamá
4.95 out of 5 average rating, 42 reviews

140 m2 apartment down town Panama-City

Corinna Rating, 5 stars2 weeks ago
Very cool neighborhood, friendly people everywhere from the front desk to anywhere we walked. The pool is just right and the kitchen had everything we needed. AC was a delight after the warm humid days, would stay again. Gerhard was super to deal with and very friendly and helpful

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