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Hotel holiday rentals in Panama City

Find and book unique hotel rentals on Airbnb

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Popular amenities for hotel rentals in Panama City

Family-friendly hotel rentals

Hotel room in San Felipe
4.9 out of 5 average rating, 40 reviews

3. Apart-Hotel Boutique- Heart of the Old City

TomasRating, 5 stars44 months ago
Absolutely amazing. Place was spaciouse, clean, well equipped. Location was right in the heart of Caso Viejo and Andres was a true gentlemen our whole stay there. I would highly recommend this place to anyone looking to stay in the heart of Casco Viejo. Dining, entertainment, sight seeing walking all walking distance. truly 5 out of 5 review.
Hotel room in San Felipe
4.9 out of 5 average rating, 48 reviews

6. Beautiful Boutique Apart-Hotel Views & Services

LeeRating, 5 stars28 months ago
Wonderful Airbnb in Casco. La Isabella Suites was located in the heart of CV. Apartment was very spacious and comfortable. A balcony overlooked a beautiful park. Great stay. Highly recommended!
Private room in Panama City
3.86 out of 5 average rating, 7 reviews

Private Five Guest Room. Hab. #2

JeimmyRating, 5 stars17 months ago
The young man at the front desk is very friendly. Just check that the location is correct as I used the one that was on the reservation and it took me somewhere else. We spent the night quietly. The smallest space I thought of. I recommend it.
Hotel room in San Felipe
5 out of 5 average rating, 33 reviews

4. Heart of the Old Town: Boutique Apart-Hotel

ChelseaRating, 5 stars17 months ago
This place is gorgeous and has all the amenities. We wish we could have stayed longer. we arrived with a car and had prepaid to park in their small ramp. We thought the car would have GPS but it didn't so we realized we needed SIM cards to get around the country. Rodrigo checked us in and it was five star service from the start. He then walked us to shops until we found and purchased a SIM for our phones. The instructions were in Spanish so he then helped us set up the SIM cards. He did an informal walking tour and showed us some recommended restaurants so we could have dinner. The location is awesome and surrounded by great restaurants and shops in the heart of Casco Viejo. The rooms are gorgeous and the balcony's are fantastic for watching the bustling town. We couldn't recommend this place more!
Hotel room in San Felipe
4.92 out of 5 average rating, 49 reviews

5. Beautiful Boutique Apart-Hotel-Views & Services

JeffRating, 5 stars29 months ago
The place was gorgeous and the staff was super friendly, helpful, and attentive. The location couldn't be any better for exploring Casco Viejo.
Hotel room in San Felipe
4.89 out of 5 average rating, 38 reviews

2. Boutique Apart-Hotel- Heart Old City

AndreaRating, 5 stars26 months ago
isabella Suites is a lovely apartment, comfortable and very well situated. Andres and all the staff were friendly and very helpful. My family and I really enjoyed our stay at Isabella Suites and the Casco Antiguo of Ciudad de Panama.
Private room in Panamá
4.33 out of 5 average rating, 3 reviews

Private Room #4. 3 people

RobertoRating, 5 stars27 months ago
Comfortable and quite focused place for backpackers. The photographs match the place. A good price.
Private room in Panamá
3.86 out of 5 average rating, 7 reviews

Hostal Villa Grande - MIXED DORM 7

PepeRating, 5 stars29 months ago
I like hostels. You always meet crazy people. This one just adds up. It is sufficient

Hotel rentals with a pool

Hotel room in Veracruz
4.43 out of 5 average rating, 7 reviews

Double room in Cosy pool hotel near Veracruz beach

Sara AlmudenaRating, 5 stars14 months ago
The hotel facilities are very well, renovated and cared for and clean. Very friendly with the animals, we are very grateful for that.
Hotel room in Panamá
4.25 out of 5 average rating, 4 reviews

Jr. Suite Rm #3- Cerro Azul

CarolinaRating, 5 stars44 months ago
It was a great visit. I like how pet friendly La Semilla Ecolodge is. I hope the staff also were happy for hosting my mom, my pets, and me. It was a very relaxing experience and we loved the food! - The cook is one of the reasons I always come back :)
Hotel room in Panamá
4.44 out of 5 average rating, 18 reviews

Rainforest Suite with Breakfast! 15 min from city

RogelioRating, 5 stars15 months ago
peacefully and beautiful place...
Hotel room in El Cangrejo
4.75 out of 5 average rating, 12 reviews

Double Suite-Apartment Hotel Príncipe

DiegoRating, 5 stars26 months ago
Great service and arrival
Hotel room in Marbella

In the heart of the city.

CristinaRating, 5 stars1 month ago
My stay at Hotel Mío in Panama City was wonderful. The place is simply unbeatable - it's incredibly located, right in front of the city's most iconic skyscrapers and buildings, offering a spectacular view. The pool on the rooftop is beautiful and perfect for relaxing. Also, breakfast is included and is delicious. The hotel itself is beautiful, modern and cozy; I would definitely always come back to stay here every time I visit Panama. I want to make a special mention to Josué, from the restaurant area, whose attention was excellent and really made my experience even better. I highly recommend this hotel!
Hotel room in El Cangrejo

Deluxe King, Marinn Place, Complimentary Breakfast

JairoRating, 5 stars3 weeks ago
All good
Hotel room in Panamá
3.75 out of 5 average rating, 4 reviews

Hotel Room with one full bed

RobertoRating, 5 stars3 weeks ago
very good place
Guest favourite
Private room in Panamá
5 out of 5 average rating, 15 reviews

Mandalas Ecolodge, Altos de Cerro Azul

MonserratRating, 5 stars2 weeks ago
It was lovely, a weekend to disconnect with a beautiful view, a super cozy and nice cabin, Shirlen was always friendly and available at all times, I would definitely come back ✨🫶🏼

Hotel rentals with a patio

Private room in Panamá
4.75 out of 5 average rating, 4 reviews

Harpy Eagle Room in Treehouse

PatriciaRating, 5 stars7 months ago
We loved the place, very nice and relaxing. The kitchen quite equipped, I would only recommend having a coffee machine and a little more of usencilios or crockery for groups of more than two people.
Private room in Panamá
3.8 out of 5 average rating, 5 reviews

Kakún Room 12, Cable TV, Refrigerator, Air Conditioning.

JimmyRating, 5 stars40 months ago
Awesome place in a very nice neighbourhood. One of the most spacious rooms I had so far with a private bathroom and a fridge. Shared kitchen has everything you need and grocery stores and restaurants at walking distance. Friendly staff, fast and stable internet. Highly recommended great value for your money.
Hotel room in El Cangrejo
3.72 out of 5 average rating, 18 reviews

Deluxe Room with 2 Double Beds

AndresRating, 5 stars8 months ago
excelente lugar super recomendado
Hotel room in Panamá

Unique | Deluxe | Private Room

RebekkaRating, 5 stars11 months ago
a lovely oasis, green and colorful, in the middle of the city :)
Private room in Punta Pacifica
5 out of 5 average rating, 3 reviews

Casa Orquídea Panama City #1

Eric And DebbieRating, 5 stars4 months ago
Perfect for our one night stay. Large, quiet place with a comfortable bed. Coffee and restaurants short walks away. Be aware about 40 steps .
Private room in Panamá

NEW! Room#11+kitchen+WiFi+AC+BBQ at @Panamá

LurysRating, 5 stars15 months ago
For the price, it was a good place
Hotel room in El Cangrejo
4.45 out of 5 average rating, 66 reviews

Grand Internationa Hotel - King Room

BartleyRating, 5 stars1 month ago
does the job especially if u need a quick room for a layover.. nothing fancy just a room, shower, and food!
Superhost
Hotel room in Panamá

Charming Hotel in Casco Viejo Santa Ana Deluxe

Quick stats about hotel rentals in Panama City

  • Total rentals

    120 properties

  • Nightly prices starting at

    ₹865 before taxes and fees

  • Total number of reviews

    2.8K reviews

  • Pet-friendly rentals

    20 properties allow pets

  • Rentals with a pool

    30 properties have a pool

  • Rentals with dedicated workspaces

    90 properties have a dedicated workspace

Destinations to explore

  1. Airbnb
  2. Panama
  3. Panamá Province
  4. Panama City
  5. Hotel rentals