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Holiday rentals in La Mesa

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in La Mesa

Guests agree: these stays are highly rated for location, cleanliness and more.

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Guest favourite
The exterior of the property features a unique adobe-style facade with soft, muted colors. A turquoise garage door is visible, accented by desert landscaping that includes stone paths and colorful flowering plants, set against a clear blue sky.
Home in Las Cruces
4.92 out of 5 average rating, 158 reviews

Beautiful, CLEAN, Comfortable with EARLY Check in

You will absolutely love this beautiful property on Airbnb. This town house is located in a quiet neighborhood & very convenient to shopping, restaurants & interstate access. This home is perfect for retirees looking for a winter home, traveling nurses, work related travel, NMSU families, etc. I welcome long term Snowbirds! Las Cruces is rated on the top list of "Best places to Retire". We have great weather & most of all "friendly folks"! I look forward to your stay! Check-in at noon!

Guest favourite
The living area features a blend of modern and artistic design, showcasing a leather sofa, a wicker chair, and a turquoise armchair. A wooden coffee table is centrally located, accompanied by a small side table. Natural light highlights the rich wood flooring and art on the walls.
Barn in Anthony
4.96 out of 5 average rating, 406 reviews

La Union Penthouse Apartment

Just remodeled and updated! Originally designed by Contemporary Artist, Willie Ray Parish. A huge, paradoxically cozy space, ideal for the traveling couple with a single Queen sized bed; it occupies approximately 1600 square feet on the top floor of a former cotton gin warehouse surrounded by a 2-acre Permaculture experiment. It is the private "Penthouse Apartment" amidst multiple communal and shared spaces on the property. Creative touches everywhere you look. A truly unique experience.

Top guest favourite
A vibrant yellow casita is framed by a rocky landscape and native vegetation. Large windows and a covered porch are visible, inviting natural light. The casita's exterior showcases a blend of rustic charm and modern design, set against a clear blue sky.
Guest house in Las Cruces
4.98 out of 5 average rating, 194 reviews

Raven's House

Casita De Cuervo is a beautiful detached casita. This spacious & quiet casita is very close to popular hiking trails and feels remote while being less than 15 minutes from I-25, NMSU, and both hospitals. This home has a full kitchen, king bed, open living room, work nook, bar stool dining, & much more. Dogs are welcome - there is an enclosed side yard with tall walls for your use. Enjoy the sunrise over the Organ Mountains on the back porch and breathtaking sunset views over the city.

Top guest favourite
A private porch area features colorful blue chairs and a grill, providing a relaxed outdoor space. A hot tub is visible to one side, and the vintage Airstream reflects sunlight with its polished exterior. String lights overhead enhance the inviting atmosphere.
Tiny home in Mesilla Park
4.93 out of 5 average rating, 255 reviews

Airstream Airdream w hot tub!

Welcome to the “Retro Retreat,” a 1968 Land Yacht infused with NM’s enchantment. This vintage stay has been lovingly curated with elements of nostalgic Americana and contemporary desert chic, featuring vintage books, games, and iconic art. This fully restored tiny stay set amidst a pecan field in the Mesilla Park district offers modern amenities including a remodeled bathroom with shower, Wi-Fi, Smart TV, a mini-split for easy heating and cooling, and a private hot tub for relaxation.

Top guest favourite
A bright interior features a queen bed adorned with geometric patterned bedding. Adjacent to the bed, two armchairs offer comfortable seating. A small loft area with a twin bed is visible overhead. A mirror and lamps provide additional lighting in the room.
Tiny home in La Mesa
4.97 out of 5 average rating, 204 reviews

Little House with Private Patio and Hot Tub

Our guesthouse is located on historic Highway 28, also known as the Don Juan de Onate Trail, which connects El Paso and Las Cruces. It is one of the area's most scenic routes. You can find breweries, multiple wineries, and the famous Chopes restaurant and bar along the route. The highlight of the 10-mile drive from our little house in San Miguel to historic Mesilla takes you through unique canopies of pecan trees, in the largest pecan-producing county in the nation.

Guest favourite
Home in Las Cruces
4.9 out of 5 average rating, 131 reviews

Pecan Palace – Luxe 4BR w/ Hot Tub, Game Room & EV

Pecan Palace: luxe 4-BR near NMSU & White Sands. Tucked by pecan farms, this new retreat blends comfort + fun. Perfect for families, work trips, extended stays. ☞ EV charger ☞ Backyard hot tub under pergola ☞ Climate-controlled game lounge with pool table ☞ Foosball ☞ Poker ☞ Pac-Man ☞ Fully equipped chef's kitchen ☞ Plush bedrooms with blackout curtains ☞ Prime spot—1.5 mi to NMSU, Interstate I-10, dining & shopping ☞ Easy access to White Sands NP and downtown

Top guest favourite
An adobe-style home is displayed, featuring a gravel pathway leading to an entrance framed by wooden gates. Two turquoise chairs sit beside a small table under a budding tree. Planted flowers in bright pots add color to the exterior, enhancing the welcoming appearance.
Home in Mesilla
4.98 out of 5 average rating, 169 reviews

Sombra Del Valle in Historic Mesilla.

Sombra Del Valle is a beautiful home located in a quiet neighborhood and within 5 minute walking distance to the historic Mesilla plaza and 2 minute walking distance to a Brewery and restaurant and approximately 5 minute drive to NMSU. The home is comfortable and spacious; great for family trips, honeymoons, or just a fun getaway. There is free guest private parking. Once you stay here you will want to come back; it’s a home away from home.

Top guest favourite
A modern interior features a wooden dining table with two black chairs, accompanied by a decorative bowl. A wall hanging adds texture, while a metal rack displays clothing and a woven basket. Natural light filters through a nearby window, highlighting the clean lines of the space.
Guest house in Mesilla
4.99 out of 5 average rating, 207 reviews

Yucca Casita in Historic Mesilla

Mesilla STR Permit #0830 We have created a sustainable design, including rainwater harvesting and water saving landscaping, solar energy, energy saving and efficient construction, electric vehicle charger (which is solar powered), composting, organic gardens, firepit, and labyrinth.This is the 3rd unit (Yucca Casita) that we've completed, the 1st being our home and 2nd our other vacation rental property - Ocotillo Casita.

Superhost
A spacious living area features a large gray sectional sofa with decorative cushions. A wooden coffee table sits in front, while light fixtures illuminate the room. The kitchen area is visible in the background, showcasing white cabinets and a decorative tile backsplash.
Home in Las Cruces
4.88 out of 5 average rating, 277 reviews

4 Bedroom Contemporary Model home

This fully-furnished modern home is perfect for weekend getaways or longterm stays. With 4 bedrooms and plenty of space The Dove Escape offers the comfort of home with a luxury feel. This stylish modern space is perfect for families, groups, or anyone seeking a retreat at the end of long day in Las Cruces or a break from the road. The Dove escape is minutes from NMSU and the University Corridor with all it has to offer.

Top guest favourite
A charming casita features a turquoise door and a light exterior, framed by subtle landscaping. The sky is filled with vibrant orange and yellow hues as the sun sets, creating a striking contrast against the white walls and windows.
Guest house in Mesilla
4.99 out of 5 average rating, 216 reviews

Cozy Casita De Mesilla (Mesilla Cottage)

Cozy casita just steps from Old Mesilla’s historic plaza and coffee shops. Unwind in your private courtyard with a hot tub, or curl up by the fireplace inside the guesthouse. A kitchenette adds comfort for longer stays. Mesilla Bosque State Park by the Rio Grande is only 4 minutes by car—or a short bike ride—perfect for birdwatching, sunsets, and peaceful walks. The ideal spot for a romantic getaway or quiet retreat.

Top guest favourite
A welcoming living area features a modern design with a sectional sofa, a sleek coffee table, and a flat-screen television mounted on an embellished wall. A textured white fireplace serves as an elegant focal point, complemented by a decorative mirror and natural greenery in the corner.
Home in Las Cruces
4.95 out of 5 average rating, 186 reviews

New Modern/Cozy Spacious Home

Find comfort in this new home in a safe neighborhood! Stylish place to stay and is perfect for group or family trips. Fast wifi and a working space make it the perfect staycation for business travelers. Spacious 3 bedrooms, 2 baths can sleep up to 6 people. Enjoy cooking in the gourmet kitchen. Snuggle up next to the beautiful white quartz fireplace or sit on the patio to view the mountains at sunset.

Guest favourite
The exterior of the casita is presented, featuring a covered porch supported by wooden beams. A light-colored door and two large windows are visible, reflecting soft sunlight. Decorative plants in pots are positioned nearby, enhancing the natural desert aesthetic.
Guest house in Las Cruces
4.87 out of 5 average rating, 184 reviews

Casa Majik

A two bedroom casita with a kitchen. We have a full bath with tub and shower. Very quiet upscale neighborhood with all custom homes on 1 acre lots. Winding streets perfect for walking or biking. Less than 50 feet from the door of Casa Majik is a trail leading to "A" Mountain. Parking is for a maximum of two cars on the property. Restaurants and Memorial Hospital are 2 miles away.

Popular amenities for La Mesa holiday rentals

  1. Airbnb
  2. United States
  3. New Mexico
  4. Doña Ana County
  5. La Mesa